Krebs Cycle

Description

Joe Corbett:

"The Krebs cycle comprises a sequence of enzymatic transformations that begin when acetyl-CoA enters oxaloacetate to form citrate. The cycle proceeds through a series of well-defined steps—citrate isomerized to isocitrate, then oxidized and decarboxylated to α-ketoglutarate, followed by another decarboxylation to succinyl-CoA, and so forth, until malate is oxidized back to oxaloacetate. In this arc, the cell harvests energy-rich electrons and carbon skeletons while evolving a steady-state flux through the mitochondrial matrix. The products of the cycle include NADH and FADH2, which carry high-energy electrons to the electron-transport chain; GTP (or ATP in some tissues) produced directly in one of the steps; carbon dioxide released along the way; and the regeneration of oxaloacetate to restart the cycle. Conceptually, this sequence is a pattern of extraction and regeneration: a finite input (acetyl-CoA) is transformed, its energy is captured in carrier molecules, and a key starting molecule is replenished to enable continuous operation."

(https://holo.substack.com/p/spiritual-biology-and-cosmo-autopoiesis)